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Beijing Gleckes Bio-engineering Technology Co. LTD. is located at No. 21, Shuiyuan Road, Miyun Economic Development Area of Beijing, adjacent to the Beijing-Chengde Expressway. This Company focuses on both of Bio-technique development and production. Its main business is the production and sale of Gleckes new food material r-aminobutyric acid (GABA), which is fermented by lactic acid bacteria Lactobacillus hilgardii. As a professional manufacturer and supplier of series of r-aminobutyric acid products, the Company owns an annual output of 100 tons of r-aminobutyric acid.

Beijing Gleckes Bio-engineering Technology Co. LTD. was awarded QS production License by Beijing FDA in 2014. Food r-aminobutyric acid is made from L-sodium glutamate as raw material by fermentation technique of Lactobacillus hilgardii, which is essentially different from the chemical synthesized r-aminobutyric acid from the poisonous 2-pyrrolidinone as raw material. Meanwhile, food r-aminobutyric acid has significant differences from other kinds of r-aminobutyric acids such as those for feedstuff, et al, which are usually produced by fermentation of Escherichia coli or non-Lactobacillus hilgardii lactic acid bacteria, because these microorganism residues in r-aminobutyric acid products will have some negative effects on normal metabolism in human body.

Different countries have different standards of food r-aminobutyric acid. In China, the technique of food r-aminobutyric acid production must be based on No.12 Bulletin in 2009 by the Ministry of Health of the People's Republic of China on September 27, 2009. Food r-aminobutyric acid is made from L-sodium glutamate as raw material by fermentation technique of Lactobacillus hilgardii with the following processing steps, including pasteurization, cooling, activated carbon filtration, spray drying steps.

According to Food Additives National Standard (GB2760-2014) of the Peoples Republic of China, r-aminobutyric acid can be used as food additive ingredients for synthesis of various essences and spices (see Product Knowledge in website).

Chemically synthesized r-aminobutyric acid, and other kinds of r-aminobutyric acids fermented by Escherichia coli or non-Lactobacillus hilgardii lactic acid bacteria are not available for food use as nutrition in China. Otherwise, if these non-edible r-aminobutyric acids are added in people food as nutrition, it is illegal.

We have the world first-class production technique of food r-aminobutyric acid, production equipments and analysis Instruments in this company. A novel analysis method to distinguish r-aminobutyric acid of chemical synthesis and r-aminobutyric acid of fermentation by lactic acid bacteria was developed by company researchers. This Company has a series of advanced bio-fermentation reactors, and biological engineering down-stream isolation and extraction equipment. The Company's Research and Development Center owns a variety of testing instruments, ensuring r-aminobutyric acid product quality. The first-class bio-engineering technology research and development working team with an advanced mechanical workshop provides professional r-aminobutyric acid production capacity.

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Gamma aminobutyric acid (GABA) is a non-protein type of amino acid . It is an inhibitory neurotransmitter in the central nervous system. GABA exists widely in human body with the highest concentration in brain nervous system, and minor amount in peripheral tissues and organs such as kidneys, liver and blood vessels. GABA is involved in many metabolic activities with very important physiological functions. It can calm down anxiety, reduce blood pressure, nourish brain, improve mental intelligence, improve memory and promote better sleep. Taking the recommended dietary allowances of GABA daily helps cardio-cerebral blood pressure relief, promotes balance of amino acid metabolism in human body, and regulates immune function.

GABA was approved as new resource food by the Ministry of Health of Japan in 2001. GABA was listed as food by Taiwan's Department of Health in 2005. Currently, GABA is widely used in foods, functional foods, and dietary supplements, and even in cosmetics in many developed countries, such as Japan and the United States.

GABA was approved as new resource food in No.12 Bulletin in 2009 by the Ministry of Health of the People's Republic of China on September 27, 2009. It can be used in beverages, cocoa products, chocolate and chocolate products, candies, baked goods, puffed foods. However, new resource food GABA can only be produced from fermentation technique of Lactobacillus hilgardii with L-sodium glutamate (Monosodium glutamate) as raw material. GABA produced by chemical synthesis and fermentation of Escherichia coli are not allowed as food because it contains harmful substances to human body, even though its purity is higher than that of new resource food GABA.


    GABA is a kind of white crystal or crystalline powder. Its chemical name is 4- aminobutyric acid.  The molecular formula is C4H9NO2 Its molecular weight is 103.1. GABA physical and chemical properties include the following, lobular crystal (methanol and diethyl ether), acicular crystal (water and ethanol), pH:6.5 ~ 7.5, melting point 197-204 ℃. At 25 ℃, the dissociation constant Ka is 3.7 × 10-11, and Kb 1.7×10-10. It is soluble in water, slightly soluble in hot ethanol, and insoluble in other organic solvents. Above the melting point, GABA decomposes to form 2-pyrrolidone and water.

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